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KMID : 0366220140490040241
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Korean Journal of Hematology
2014 Volume.49 No. 4 p.241 ~ p.245
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Aberrant myeloid antigen co-expression is correlated with high percentages of CD34-positive cells among blasts of acute lymphoblastic leukemia patients: an Indian tertiary care center perspective
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Sharma Rahul Kumar
Purohit Abhishek
Somasundaram Venkatesan
Mishra Pravas Chandra
Kotru Mrinalini
Ranjan Ravi
Kumar Sunil
Sazawal Sudha
Pati Hara Prasad
Tyagi Seema
Saxena Renu
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Abstract
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Background: Aberrant myeloid antigen (MA) co-expression and high expression of CD34 antigen on the blasts of acute lymphoblastic leukemia (ALL) patients are independently reported to have a role in pathogenesis and prognosis. This study was conducted to determine wheth-er these two parameters are related.
Methods: A total of 204 cases of ALL were included in an analysis of blast immunophenotypic data. CD34 expression was categorized as low when less than 50% of blasts were CD34-pos-itive (CD34low) and as high when 50% or more were CD34-positive (CD34high).
Results: Of 204 cases of ALL, 163 and 41 were of B-cell origin (B-ALL) and T-cell origin (T-ALL), respectively. Of all cases, 132 (64.7%) showed co-expression of MA and among these, 101 (76.51%) were CD34high, while the remaining 31 (23.48%) were CD34low. Of 72 cases without MA co-expression, 25 (34.72%) were CD34high and 47 (67.25%) were CD34low. Furthermore, of 163 cases of B-ALL, 111 showed co-expression of MA and 84 of these were CD34high. Of 52 cases of B-ALL without MA expression, 22 were CD34high. Among 41 cases of T-ALL, 21 co-expressed MA, 17 of which were CD34high. Moreover, all 20 cases of T-ALL without co-expression of MA were CD34low. These differences were statistically significant.
Conclusion: We observed a strong correlation between aberrant MA expression and CD34high ex-pression on the blasts of ALL. We hypothesize that these different patient subsets may represent unique prognostic characteristics.
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KEYWORD
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CD34, Acute lymphoblastic leukemia, Immunophenotyping, Aberrant myeloid antigen co-expression, Flow cytometry
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